Issues

• Worker process pool holds about 4 GB while idle, leaving too little memory for the mapper's BLAT

  app: worker
  Bug

  VariantEffect/mavedb-api#952 · Filter by author bencap opened on Oct 23, 2026 · R2026.4

• Move blocking work in async routes off the event loop

  app: backend
  Task

  VariantEffect/mavedb-api#950 · Filter by author bencap opened on Oct 23, 2026 · R2026.4

• Reference publications by their identifier so citations can be written under RLS

  app: backendapp: database
  Task

  VariantEffect/mavedb-api#945 · Filter by author bencap opened on Oct 21, 2026 · R2026.4

• Store DOI, raw read and target gene identifiers on the rows that use them

  app: backendapp: database
  Task

  VariantEffect/mavedb-api#944 · Filter by author bencap opened on Oct 21, 2026 · R2026.4
  

• Derive variant URNs from the score set so publishing doesn't rewrite every variant

  app: backendapp: database
  Task

  VariantEffect/mavedb-api#940 · Filter by author bencap opened on Oct 21, 2026

• Store each variant's number in its own column

  app: backendapp: database
  Task

  VariantEffect/mavedb-api#939 · Filter by author bencap opened on Oct 21, 2026

• Refuse reference-identical alleles whose VRS state doesn't cover the sequence

  app: worker
  Task

  VariantEffect/mavedb-api#935 · Filter by author bencap opened on Oct 19, 2026

• Run the stalled-job sweeper's cron on the fast-lane worker

  app: worker
  Bug

  VariantEffect/mavedb-api#934 · Filter by author bencap opened on Oct 19, 2026

• Read mapping output from TargetGeneMapping and drop it from TargetGene

  app: backendapp: databaseapp: worker
  Chore

  VariantEffect/mavedb-api#932 · Filter by author bencap opened on Oct 15, 2026 · R2026.4

• Record per-target mapping output on TargetGeneMapping

  app: backendapp: databaseapp: worker
  Feature

  VariantEffect/mavedb-api#931 · Filter by author bencap opened on Oct 15, 2026 · R2026.4

• Mapped-gene list and statistic drop a score set whenever it's re-mapped

  app: backend
  Bug

  VariantEffect/mavedb-api#930 · Filter by author bencap opened on Oct 15, 2026 · R2026.4

• Serve the submitted level apart from the mapper's alignment layer

  app: backend
  Feature

  VariantEffect/mavedb-api#929 · Filter by author bencap opened on Oct 15, 2026 · R2026.4

• Drop the mapping record's duplicate level column

  app: backendapp: databaseapp: worker
  Chore

  VariantEffect/mavedb-api#928 · Filter by author bencap opened on Oct 15, 2026 · R2026.4

• Keep investigator-submitted facts and mapping-derived facts apart

  app: backendapp: databaseapp: worker
  Epic

  VariantEffect/mavedb-api#927 · Filter by author bencap opened on Oct 15, 2026

• Serve splicing and NMD detection as assay facts in API responses

  app: backendapp: databaseapp: frontend
  Feature

  VariantEffect/mavedb-api#924 · Filter by author bencap opened on Oct 14, 2026 · R2026.4

• Let API clients list official collections and filter score set search by them

  app: backend
  Feature

  VariantEffect/mavedb-api#923 · Filter by author bencap opened on Oct 14, 2026 · R2026.4

• Model ClinGen alleles like other external sources

  app: databaseapp: worker
  Epic

  VariantEffect/mavedb-api#922 · Filter by author bencap opened on Oct 12, 2026

• Score set 00000663-a-1's nucleotide variants are two bases off from their protein variants

  app: database
  Bug

  VariantEffect/mavedb-api#921 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Warn at upload when a row's nucleotide and protein variants describe different changes

  app: backend
  Feature

  VariantEffect/mavedb-api#920 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Store allele ClinGen allele IDs as valid-time links

  app: backendapp: databaseapp: worker
  Chore

  VariantEffect/mavedb-api#919 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Record ClinGen allele facts in the database instead of Redis

  app: databaseapp: worker
  Chore

  VariantEffect/mavedb-api#918 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Rate-limit by user and tier in the API, with the WAF as a per-IP backstop

  app: awsapp: backend
  Feature

  VariantEffect/mavedb-api#917 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Choose how whole-set responses are cached and revalidated

  app: awsapp: backend
  Spike

  VariantEffect/mavedb-api#916 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Build bulk response rows without validating each through Pydantic

  app: backend
  Chore

  VariantEffect/mavedb-api#915 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Measure where time and bytes go when serving whole score sets

  app: backend
  Spike

  VariantEffect/mavedb-api#914 · Filter by author bencap opened on Oct 9, 2026 · R2026.4